A novel mechanism of synaptic and cognitive impairments mediated via microRNA-30b in Alzheimer's disease

Cognitive Impairments in Siblings of Alzheimers Disease Patients: Possible Preclinical Signs of the Disease

wuthering heights and the concept of marality/a sociological study of the novel

to discuss my point, i have collected quite a number of articles, anthologies, and books about "wuthering heights" applying various ideas and theories to this fantastic story. hence, i have come to believe that gadamer and jauss are rightful when they claim that "the individaul human mind is the center and origin of all meaning," 3 that reading literature is a reader-oriented activity, that it ...

Neurobiology of Disease Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer’s Disease

Jeannie Chin,1,2 Jorge J. Palop,1,2 Jukka Puoliväli,1,2 Catherine Massaro,1,3 Nga Bien-Ly,1 Hilary Gerstein,1 Kimberly Scearce-Levie,1 Eliezer Masliah,4 and Lennart Mucke1,2,3 1Gladstone Institute of Neurological Disease, 2Department of Neurology, and 3Neuroscience Graduate Program, University of California, San Francisco, San Francisco, California 94158, and 4Departments of Neurosciences and P...

Role of microRNA as a biomarker in Alzheimer’s disease

Introduction: MicroRNAs are small, non-coding, and protected RNA molecules that regulate gene expression after transcription by mRNA degradation or inhibition of protein synthesis. The function of these molecules is critical to many cellular processes, including growth, development, differentiation, homeostasis, apoptosis, aging, stress resistance. In addition, some diseases including cancer, a...

MicroRNA-30b-Mediated Regulation of Catalase Expression in Human ARPE-19 Cells

BACKGROUND Oxidative injury to retinal pigment epithelium (RPE) and retinal photoreceptors has been linked to a number of retinal diseases, including age-related macular degeneration (AMD). Reactive oxygen species (ROS)-mediated gene expression has been extensively studied at transcriptional levels. Also, the post-transcriptional control of gene expression at the level of translational regulati...